Fetal retinoblastoma cannot usually be detected in pregnancy. Retinoblastoma is a malignant tumor that originates in the retina and is the most common malignant tumor of the eye in infants and children. Retinoblastoma is rare in adults and occurs in children under 3 years of age. This tumor is not detected during the usual pregnancy tests. Only the two orbits of the fetus can be observed during pregnancy, and there is no requirement for fetal eye examination in routine checkups. DNA testing is required if there is a relevant family history, but there is no systematic development of such tests in our country. Strictly good maternity examination during pregnancy, observe the fetus at any time, may want to carry out newborn fundus retina screening at an early stage. To achieve early detection, early diagnosis, early treatment.