There is no such thing as gout eating diclofenac sodium and colchicine which effect is better, the two belong to two different types of anti-inflammatory drugs, their pharmacological effects, drug indications, adverse reactions, contraindications, etc. There are differences in the therapeutic effect and the patient’s personal situation. 1. Pharmacological effects: Diclofenac sodium is a non-steroidal anti-inflammatory drug, mainly through the inhibition of human cyclo-oxygenase to play the role of antipyretic, analgesic, anti-inflammatory effect; colchicine is mainly through the inhibition of leukocyte chemotaxis, reduce the release of prostaglandins and leukotrienes, inhibition of interleukin-6 production and other pathways to play an anti-inflammatory effect. 2. Indications: Diclofenac sodium can be used for rheumatoid arthritis, ankylosing spondylitis and other inflammatory and degenerative diseases, acute attacks of gout, postoperative and post-traumatic factors such as pain; colchicine is mainly used for the treatment of acute attacks of gout. 3. Adverse reactions: common adverse reactions of diclofenac sodium include headache, nausea, vomiting, dyspepsia, diarrhea, etc. Common adverse reactions of colchicine include diarrhea, abdominal pain, proximal muscle weakness, thrombocytopenia, alopecia, rash, etc. 4. Contraindications: Diclofenac sodium is contraindicated in drug allergy; colchicine is contraindicated in myeloproliferative hypoplasia and impaired hepatic and renal function. The effect of both treatments for gout is related to the patient’s personal situation, different people have different sensitivities to the drugs, and the efficacy may be different. Diclofenac sodium and colchicine should be used under the guidance of a physician, and it is recommended that gout patients who need to take these two drugs go to the rheumatology and immunology department of a regular hospital for detailed consultation.