Symptoms of seronegative rheumatoid arthritis include joint pain in the toes and hands, morning stiffness and edema. Seronegative rheumatoid arthritis is rheumatoid arthritis that is negative for rheumatoid factor and anti-cyclic citrullinated peptide antibodies. It is usually regarded as a special subtype of rheumatoid arthritis. The clinical manifestations are similar to those of rheumatoid arthritis, including morning stiffness, joint swelling and pain, and edema, etc. The affected joints are mainly the large joints, and the duration of morning stiffness is shorter. Seronegative rheumatoid arthritis has a later age of onset relative to seropositive rheumatoid arthritis, and may present with increased blood sedimentation, anemia, and hypoproteinemia. In addition to the clinical manifestations and laboratory tests, imaging studies should be combined to avoid missed diagnosis. It is recommended that patients diagnosed with seronegative rheumatoid arthritis go to the Department of Rheumatology and Immunology of a regular hospital for relevant consultation.