Adapalene is an anti-acne medication. If the skin peels off after use, it may be due to an adverse reaction to the medication, which can be alleviated by moisturizing the skin or applying spot-on creams, or the medication can be discontinued if it is still intolerable. Adapalene is mainly used for the treatment of pimples, acne vulgaris and pustules; it can also treat acne on the face and chest and back. Adapalene is contraindicated in pregnant women, nursing mothers, and patients who are allergic to the components of the drug Adapalene. Patients may experience adverse reactions such as erythema, scaling, flaking, itching, burning, dryness, and stinging after using Adapalene. When using Adapalene, avoid contact with mucosal tissues such as the eyes, oral cavity, nasal mucosa. Patients need to pay attention to sun protection. Clinical use of adapalene may lead to peeling, but the peeling can usually be reduced by means of spot application of adapalene gel or increased moisturization. If there is still no effective improvement, or they can not tolerate, you can choose to stop the drug observation. If the peeling is still not relieved after a period of observation, it is necessary to consult a regular hospital to avoid delaying the condition.