Hand, foot and mouth disease in children is a newly recognized disease in the last few years. It is characterized by fever, loss of appetite, runny nose, and sore throat. These symptoms usually appear within 3-5 days after infection, and 1-2 days after the start of the signs, a not-too-big blister-like rash appears on the palms of the hands, fingers, soles of the feet, periapical region, tongue, throat, mouth, and around the anus, and the disease usually lasts 7-10 days with few complications. Since the disease is a viral infection and highly contagious, there is a clear epidemiological history. The general period of transmission is from the initial appearance of the disease until the blister-like rash subsides, and the mode of transmission is by contact. In addition, since the virus is excreted in the stool of sick children and the fluid in the blisters is also virus-bearing, transmission by other routes cannot be ruled out. The disease usually occurs in children under the age of 10 years, but it also occurs in a few young adults. The main culprit is coxsackievirus A16 or A5 or A10, which causes a blistering rash on the hands, feet, and mouth, and is spread by direct contact with the blistering fluid, nasal discharge, droplets, or feces of the patient. Diagnosis of HFMD: HFMD can generally be diagnosed from a blistering rash on the hands, feet, and mouth, as well as from a mild fever. Immunity after HFMD infection: After the first HFMD infection, the patient develops specific immunity, but there is a risk of infection with other types of coxsackieviruses, and very few individuals are immunocompromised and may be re-infected. Treatment of HFMD: There is basically no specific treatment for HFMD, except for controlling fever and keeping the mouth moist. Prevention: Children who feel unwell or have a fever should be isolated from other children until the fever subsides and the condition improves. Both children and adults should wash their hands thoroughly and cleanly. In addition, the medical community is still inconclusive as to whether coxsackievirus infection causes fetal teratogenicity.