There is no scientific evidence for the claim that abnormalities on hands are mostly liver cancer, but if there are red palms, spider moles, etc., we need to be alert to liver diseases. If liver cancer patients have decompensation of liver function, the metabolic inactivation function of estrogen occurs with different degrees of obstacles, estrogen accumulates in the body, stimulates congestion and expansion of capillary arteries, and in the long run, it forms pink spots and plaques on palmar surfaces of palms of both hands with large and small fissures and fingertips. However, other liver diseases and normal people also have the manifestation of liver palms. Therefore, if the above symptoms occur, it is recommended to seek early medical treatment to clarify the cause of the disease.