Duodenal mesenchymal tumor is too big and can be operated. Mesenchymal tumor is one of the common lesions in gastrointestinal tract, with complex causes, which may be related to genetic factors and other conditions, and the nature of the lesion is not clear, with benign lesions and malignant lesions. Generally, the lesion is benign in the early stage, and with the development of the lesion, cancer may occur. In some patients, the lesions are small and may not have obvious clinical symptoms. As the lesion gradually develops and becomes larger, the lesion may block the intestinal tract, inducing the patient to experience abdominal pain, nausea and vomiting, dyspepsia, blood in the stool, and other symptoms. Surgery is often recommended for patients with obvious symptoms or for those who are considered to have malignant lesions. Duodenal mesenchymal tumors are too large and can lead to space-occupying effects. There are no specific drugs that can shrink or eliminate mesenchymal tumors, and surgery can be considered when surgical indications are met. Mesenchymoma is not a contraindication to surgery, patients should not be too nervous, and actively cooperate with the doctor to complete the surgery. After surgery, the patient needs to further analyze the specific condition through pathological examination, and actively cooperate with the doctor for treatment to ensure smooth recovery after surgery.