Ibuprofen has fewer side effects compared to Compound Zinc Cloth Granules. The main ingredients of Compound Zinc Cloth Granules are chlorpheniramine maleate, zinc gluconate, ibuprofen, and various excipients. It has antipyretic and analgesic effects and is suitable for relieving headache, fever, limb pain, runny nose, nasal congestion, sneezing and other symptoms caused by colds. A few patients may experience adverse reactions such as heartburn, nausea and gastrointestinal bleeding. Ibuprofen is antipyretic and analgesic by inhibiting prostaglandin synthesis. It is suitable for the treatment of headache, toothache, arthralgia, neuralgia, migraine and dysmenorrhea, etc. It is generally less likely to have adverse reactions, but long-term use of ibuprofen may have gastrointestinal adverse reactions, such as gastric pain, dyspepsia, nausea and vomiting and other adverse reactions. The scope of application of the two is different, ibuprofen is a kind of non-steroidal and safe anti-inflammatory drugs, the efficacy of the drug is better, the side effects are smaller, it is a kind of over-the-counter drugs; compound zinc cloth granules is also a kind of over-the-counter drugs, the treatment of viral colds, influenza is more effective, but it is bigger than the side effects of ibuprofen. In short, patients should take the drugs under the guidance of a specialist physician and follow the doctor’s instructions.