Cirrhosis and chronic nephritis stage 4 can be treated at the same time, both diseases are serious diseases, specifically which disease to see first can be based on the condition of the doctor’s prescription treatment. Cirrhosis and chronic nephritis stage 4 at the same time, mostly consider the hepatorenal syndrome, refers to the occurrence of severe liver disease when the functional acute renal failure, the clinical condition will be abnormal development. The need to remove the cause of the disease, but also to correct the water-electrolyte balance, acid-base balance, etc., have a role in hepatorenal syndrome. Cirrhosis and chronic nephritis stage 4 can be treated simultaneously with vasoactive drugs, such as terlipressin can improve the effective circulating blood volume, increase renal blood flow, and block the activation of renin-angiotensin-aldosterone system, which can be used in functional renal failure. Once hepatorenal syndrome is present and medical treatment is ineffective, liver transplantation can be performed by transjugular venous portosystemic shunt. In addition, liver cirrhosis and chronic nephritis stage 4, no matter which one is treated first, should promptly go to the regular hospital for examination to clarify the cause of the disease. After diagnosis, you must follow the doctor’s instructions to take the correct medication for long-term treatment, because the ingredients of some drugs may cause damage to the kidneys and spleen. If the drugs are not used properly, it is not only unfavorable to the recovery of the disease, but also prone to cause other diseases.