Gangrene is an extremely serious infection with degeneration, blackening and necrosis of the tissue at the site of the gangrene, most often accompanied by a foul odor, and most often occurs at the ends of the extremities in patients with diabetes or peripheral vascular disease. The treatment of gangrene is mainly to control the infection so that the gangrene does not spread, and to remove as much necrotic tissue as possible from the patient if the patient is physically able to tolerate it. If the patient is no longer able to tolerate it, only relatively conservative treatment is possible, with routine application of hydrogen peroxide, povidone-iodine or alcohol to sterilize the gangrenous area. If the infection is an anaerobic bacterial infection, the wound should be exposed to air as much as possible, and broad-spectrum antibiotics can be routinely applied. If the patient’s infection is already severe, amputation can be considered in order to prevent systemic infection.