Lung cancer with rib metastasis suggests that the disease has progressed to advanced stage, and patients can choose radiotherapy, chemotherapy and other treatments under the guidance of specialists, and some patients can choose targeted drugs or immunotherapy drugs according to special treatment targets, there is no uniform “best treatment plan”. 1. Treatment for bone metastases: rib metastases of lung cancer mostly show osteolytic damage, bisphosphonates and denosumab can be used to reduce the role of osteoclasts, delay the occurrence of osteolytic events and improve the life treatment of patients according to doctor’s instructions. For patients with isolated rib metastases, surgery can be considered to remove the tumor metastases. 2. Treatment for lung cancer: for advanced lung cancer, patients have lost the chance of surgery for primary lesions, radiotherapy, chemotherapy and other treatments can be used to limit tumor metastasis. For patients with positive special therapeutic targets, molecular targeted drug therapy or immunotherapy can be considered. 3. Others: patients with rib metastasis of lung cancer mostly have local pain, and the severe pain can seriously affect patients’ quality of life. Patients can use morphine hydrochloride tablets, oxycodone extended-release tablets and other pain-relieving drugs as prescribed by doctors. The treatment of rib metastasis of lung cancer requires specialists to choose drugs, chemotherapy, radiotherapy and other combined treatments according to patients’ specific conditions, so as to control the disease, prolong patients’ survival and improve their quality of life.