The third booster shot usually refers to the New Crown vaccine booster shot. Whether breast nodule patients can be vaccinated needs to be analyzed according to the patient’s specific condition; if it is benign, it can usually be vaccinated; if it is malignant, it is usually not recommended to be vaccinated for patients who are in the treatment period. 1. Benign: If the nodule is benign, and the patient has reached 18 years of age, and has been vaccinated with the new coronavirus vaccine for 6 months, which is in line with the demand for vaccination, he/she can have a booster shot of the new coronavirus vaccine. 2. Malignant: If the nodule is malignant and the patient is undergoing treatment such as surgery, chemotherapy, radiotherapy, etc., a booster shot of the New Crown Vaccine is not allowed within a short period of time, or it may aggravate the adverse reaction of the vaccine. Some people will experience redness, swelling, itching and hard nodules at the vaccination site after receiving the booster shot of New Crown Vaccine, and a few people may experience dizziness, fatigue, or even fainting, so they need to observe for half an hour before leaving after vaccination to avoid adverse reactions. It is recommended to inform your doctor of your condition when you get vaccinated, and the doctor will decide whether to give a booster shot of New Crown Vaccine according to the specific situation.