Pain is one of the most common symptoms in cancer patients and seriously affects the quality of life of cancer patients. The pain care of sigmoid colon cancer is usually administered using the WHO three-step pain relief principle and combined with home treatment. 1.WHO three-step analgesic principle: In practice, the first step is to assess the degree of pain, and according to the assessment result, the analgesic is given according to the three-step analgesic principle as prescribed by the doctor. Comply with the principles: give drugs according to the ladder, give drugs orally, give drugs on time, give drugs individually and pay attention to specific details. 2. Home treatment for cancer pain relief: in home treatment for cancer pain relief, for cancer patients with longer course of disease and milder pain, psychotherapy and physiotherapy should be adopted to assist pain relief. If there exists sigmoid colon cancer pain, it is necessary to communicate with the attending physician in time, and the doctor will make specific arrangements according to the patient’s situation to improve the patient’s quality of life.