Running more knee pain is common in chondromalacia patella, synovitis, ligament injury and other diseases, generally conservative treatment is the main, serious need for surgery. 1. Chondromalacia patella: prolonged pressure focused on a certain point will cause chronic injury, especially for people with joint degeneration, this situation will lead to wear and tear of patellofemoral cartilage causing joint pain. You should rest more to reduce the wear and tear of patellar cartilage. If the symptoms are obvious, sodium hyaluronate can be injected to increase the lubricity of the cartilage. 2. Synovitis: there is a small amount of synovial fluid in the bursa, when the bursa is damaged and not fully recovered, there will be a chronic inflammatory reaction, so that the surface is edema, thickening, and fibrosis, which will show obvious symptoms after exertion, such as knee pain. You can apply hot compresses to the local area or use ultrasound and other methods of treatment, you can also take oral ibuprofen, celecoxib and other drugs to relieve pain, for the more serious, you can inject prednisolone acetate plus treatment. 3. Ligament injury: If there is some more violent external impact in the running process, or the ligament is pulled for a longer period of time, ligament injury will occur in this case, resulting in pain at the injury site, activity disorders and so on. If the ligament injury is mild. Can be relieved by rest and oral pain medication, such as acetaminophen, ibuprofen, for more serious need to be treated by surgery, such as arthroscopic minimally invasive surgery. If you run a lot, you should consult a doctor to find out the cause of your knee pain and follow the doctor’s instructions. The use of the above medications should be in accordance with medical advice.