When coughing with phlegm occurs in the middle of the night, this condition is mainly due to the exudation of a large amount of inflammatory secretions in the airway, and some of the secretions will reflux into the airway until the pharynx and cause coughing. It is mainly common in acute exacerbation of chronic bronchitis, acute bronchitis, etc. At this time, choose symptomatic treatment, for example, for the symptoms of coughing and coughing with phlegm you can take appropriate coughing and phlegm-relieving drugs, choose snake bile and chuanbei liquid, snake bile and chenpi san, lantern leaf granules, myrtle oil, carboxymethylstilbestrol oral liquid, aminoglutethimide syrup, etc. For etiological treatment, if it is a bacterial infection you can choose to take antibiotics, such as amoxicillin clavulanate potassium, clindamycin, cefuroxime, levofloxacin and other drugs.