Substantial nodules in the liver are likely to be malignant, this is because the vast majority of both primary and metastatic liver cancers are substantial lesions. However, a small percentage of malignant liver tumors may be cystic lesions, such as hepatic cystic carcinoma, which is formed by malignant transformation of hepatic cystadenoma. However, parenchymal nodules may also be benign occupations of the liver, such as hepatic hemangiomas, hepatic adenomas, focal nodular hyperplasia of the liver, cirrhotic nodules, nodular regenerative hyperplasia of the liver, and partial nodular lesions of the liver. However, it should be noted that some lesions are benign in the early stage of parenchymal development, but may become cancerous with further development of the lesion, and sometimes it is difficult to determine the nature of the parenchymal nodular lesion. Therefore, close follow-up and observation should be paid attention to, especially for patients with cirrhotic nodules, if the specific nature of the nodules cannot be determined by enhanced magnetic resonance imaging or tumor markers, further clarification can be made by liver puncture biopsy.