Patient Xu Mouxiang, female, 68 years old, came to the clinic on February 16, 2016. The patient complained of left knee pain for several years, cold pain sensation, the pain worsens when the weather becomes cold and when blowing air conditioner, the pain also occurs when walking for too long and going up and down stairs, recently the appetite has become worse, sleep is poor due to pain, stool is easy to dilute, urine can be, the tongue is dull red with thin white coating, the pulse is string. Physical examination: no localized pressure pain, no redness or swelling, normal activity. Prescription: Gui Zhi 15, Bai Shao 30, Ginger 5, Jujube 15, Glycyrrhiza 15, Atractylodes Macrocephala 15, Radix Angelicae Sinensis 15, Salviae Miltiorrhizae 10, Myrrh 10, 3 doses in water, one dose daily. At the same time, acupuncture was given once every other day. On February 18, the patient came for acupuncture treatment and complained that the pain was relieved the same night he took the medicine and he had a good night’s sleep. The patient was instructed to continue treatment. Case study: Age-related knee osteoarthritis is a common disease in the elderly. Knee pain is the main symptom of degenerative arthritis of the knee joint, manifesting as dull pain, which is most obvious in the morning or after the joint has been in a certain position for a long time, and can be reduced with a little activity. The pain is most pronounced in the morning or after the joint has been in a certain position for a long time. Patients feel inflexibility in the knee joint, which is more pronounced after rest. There is stiffness in the knee joint, and the knee joint may make a rough grinding sound when moving. These symptoms may worsen as the pathology worsens. In addition to pain, there may be local swelling, exudate, muscle atrophy, and even joint deformity and limitation of movement. The patient complained of cold pain in the knee joint, which is aggravated by cold, and loose stools. With the combination of several prescriptions, although the disease is several years old, it can be relieved overnight. In the later stage, patients should further warm the kidney yang, disperse cold and remove dampness to relieve pain, reduce the number of recurrences and improve the quality of life.