Most of the thyroid nodules are benign, thyroid nodules 0.45×0.4cm whether it is important to be determined according to the nature of the nodule, benign nodules usually does not matter, malignant nodules are more serious, not timely treatment of malignant nodules will have the risk of metastasis. 0.45×0.4cm benign thyroid nodules, no clinical symptoms, usually do not need special treatment, follow the doctor’s instructions to observe the follow-up; if the nodule increases, close to the esophagus and trachea position caused by dysphagia, dyspnea, etc., can be performed thyroidectomy to relieve the compression symptoms. 0.45×0.4cm malignant thyroid nodule once diagnosed should be timely intervention, further improve the examination to clarify whether the nodule exists in the blood vessels, lymphatic or distant organs metastasis, and take timely surgery and other treatments. Patients with thyroid nodules 0.45×0.4cm should be treated under the guidance of a doctor.