There are differences between painless gastroscopy and general gastroscopy in terms of whether anesthesia is provided, subjective feelings, post-operative precautions and costs. 1. Whether anesthesia: painless gastroscopy needs general anesthesia, using propofol and other anesthetics to make the patient’s pain and consciousness disappear, while general gastroscopy does not have general anesthesia, but sometimes oral lidocaine gel and other local anesthesia in the throat. 2. Subjective perception: painless gastroscopy process of loss of consciousness, wake up after the end of the procedure. Ordinary gastroscopy without general anesthesia, gastroscope from the oral cavity into the throat may be due to pharyngeal reflex discomfort, the need for active cooperation with the patient. 3. Postoperative precautions: painless gastroscopy from the general anesthesia after waking up in 2 hours, no drinking and eating, 24 hours should not be driving and riding, ordinary gastroscopy only need to avoid the use of spicy and stimulating food within 24 hours. 4. Cost: Painless gastroscopy is more expensive than general gastroscopy because it requires general anesthesia. Both painless gastroscopy and general gastroscopy are commonly used in clinical practice, so patients are advised to fully understand the advantages and disadvantages of the two types of gastroscopy before undergoing gastroscopy, and choose the appropriate examination method according to their needs.