The knee soreness and weakness can not sleep at night should be based on the cause of the general treatment, drug therapy, physical therapy and surgical treatment, common causes are overwork, chondromalacia patella, rheumatoid arthritis and so on. 1 overwork: overworked people, such as competitive sports, miners, porters, etc., due to long-term excessive knee activities lead to chronic meniscus injury, there will be knee weakness, should pay attention to rest, avoid overwork, proper warmth of the knee, serious cases can use non-steroidal anti-inflammatory drugs such as celecoxib pain. 2. Chondromalacia patella: knee trauma, long-term wear and tear, etc., will lead to chondromalacia patella, early weakness of the knee, should limit the knee joint activities, appropriate massage, strengthen the quadriceps isometric contraction exercise exercises, serious cases can be injected intra-articular injection of sodium hyaluronate injection. 3. Rheumatoid arthritis: Rheumatoid arthritis will also appear the symptoms of knee weakness, usually accompanied by knee swelling and pain. Attention should be paid to rest and warmth, avoid cold, oral non-steroidal anti-inflammatory drugs such as diclofenac sodium extended-release tablets and methotrexate and other anti-rheumatic drugs, conservative treatment is ineffective, the emergence of deformity of the knee joints feasible knee replacement therapy. The knee is weak and achy, can not sleep at night, there may be other reasons, such as cervical spondylosis, osteoporosis, synovitis, etc., if the rest does not relieve, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, and then follow the doctor’s instructions to give targeted treatment or treatment, so as to avoid delays in the condition. All of the above drugs should be used under the guidance of a doctor.