Liver cancer patients with tumor size of 9-10cm also need active treatment, and according to their conditions, they can choose single or combined treatment such as surgical resection, interventional therapy, targeted therapy, immunotherapy and chemotherapy. According to TNM staging, hepatocellular carcinoma with tumor size of 9-10cm is at least stage T3, and if it involves portal vein/hepatic vein, invades adjacent organs outside the gallbladder or penetrates the peritoneum, it is stage T4; If there is no lymph node metastasis or distant metastasis, it is T3N0M0, stage IIIA, which can be considered as intermediate stage; if lymph node metastasis or distant metastasis occurs, or if it is T4, it is usually already stage IIIB or IV, which is advanced stage. For stage IIIA patients, if the lesions are isolated or 2-3, surgical resection, TACE, ablation, liver transplantation and other treatments can be given; if the lesions are more than 4, TACE combined with systemic anti-tumor therapy (chemotherapy, immunotherapy, targeted therapy, etc.) is usually preferred; For patients with stage IV, usually surgery is no longer the first choice or radical resection can be achieved, and anti-tumor systemic therapy (chemotherapy, immunotherapy, targeted therapy, etc.), TACE, radiotherapy and other single or combined treatments are usually recommended. It is recommended that patients diagnosed with liver cancer should go to regular hospitals to evaluate their conditions and follow the doctor’s instructions to actively cooperate with the treatment, so as to control the disease progression and improve the prognosis of the patients.