High neuron-specific enolase after lung cancer surgery mainly refers to high enolase involved in glycolysis pathway, there may still be cancer cells or the disease recurs again after surgery, at present, radiotherapy and chemotherapy can be adopted to inhibit the development of cancer cells. 1. Radiotherapy: radiotherapy, which can be chosen before surgery or after surgery, can reduce the size of the tumor and minimize local recurrence. 2. Chemotherapy: mainly use related chemotherapeutic drugs to inhibit the progression of cancer cells, for example, pedialyte glycoside + cisplatin, or vincristine + cisplatin. If the patient does not tolerate it, it can be carried out together with radiotherapy at the same time. 3. Targeted therapy: it is mainly recommended to use growth factor receptor tyrosine kinase inhibitors, representative drugs include gefitinib and erlotinib. If neuron-specific enolase is found to be high after lung cancer surgery, in addition to the above treatments, immunotherapy and nutritional supportive therapy can also be chosen according to the patient’s tolerance to medicines and the degree of physical exertion, and the specifics should be carried out in accordance with the doctor’s instruction.