If there is no response for 40 minutes after taking polyethylene glycol, you can use some topical laxatives or take a cleansing enema to clean the bowel. Polyethylene glycol is a kind of laxative, which is a commonly used drug for the treatment of constipation, and it is mainly used in clinic for the treatment of functional constipation, colonoscopy and bowel cleansing preparation before surgery. No reaction after drinking polyethylene glycol for 40 minutes needs to be treated according to the actual situation of the patient. 1. Constipation. When polyethylene glycol is used for the treatment of constipation, if there is no reaction 40 minutes after taking it, you can take the rectal administration of the drug, such as the topical use of cecrops, which is a kind of topical laxative to promote anal defecation and relieve the symptoms of constipation. 2. Bowel cleansing. When polyethylene glycol is used for colonoscopy and preoperative bowel cleansing preparation, if there is no response 40 minutes after taking it, a cleansing enema can be taken, such as the use of 0.1% to 0.2% soapy water enema. If there is no response 40 minutes after drinking polyethylene glycol, symptomatic treatment under medical supervision is recommended.