The treatment plan for multiple primary lung cancers is mainly surgery, supplemented by radiotherapy after surgery. Multiple primary lung cancer refers to the simultaneous or sequential occurrence of two or more primary lung cancers in one lung or different parts of both lungs, which have the same or different tissue types. Patients with definite diagnosis of multiple primary lung cancers without contraindications to surgery should undergo surgical treatment to remove the tumor and clear the regional lymph nodes. The surgical method depends on the patient’s general condition, cardiopulmonary function, tissue type of the tumor, specific location and stage of the tumor, as well as the form of morbidity. Surgical principles are: (1) resect central lung cancer first, then resect peripheral lung cancer; (2) resect large tumors first, then resect small tumors. After surgery, according to the tissue type and pathological staging of the tumor, appropriate adjuvant treatment such as radiotherapy, chemotherapy or comprehensive treatment should be given if necessary. The postoperative adjuvant treatment plan should be formulated based on the side with later staging. If multiple primary lung cancers are diagnosed, early standardized treatment is recommended to reduce the adverse effects of the disease.