Hepatitis C generally refers to Hepatitis C. Having Hepatitis C for 30 years can have serious consequences if it is not actively treated. If left untreated in the early stages, the hepatitis C virus will damage liver cells bit by bit over time, causing chronic inflammation, necrosis, and liver fibrosis in the liver, which will further lead to cirrhosis, liver cancer, and ultimately threaten the patient’s life and cause death. Hepatitis C infection can cause a variety of extrahepatic complications, including autoimmune thyroid disease, type 2 diabetes mellitus, renal damage, neurological disorders, cardiovascular diseases, as well as hepatitis C infection-associated cryoglobulinemia and its resultant systemic vasculitis, hepatitis C virus-associated nephritis, and non-Hodgkin’s B-cell lymphoma, delayed-onset dermatopathies, fatigue and weakness. The common extrahepatic manifestations of hepatitis C infection in China are characterized by fatigue, type 2 diabetes mellitus, renal impairment, lymphadenopathy, fever, and hypothyroidism. Therefore, patients with hepatitis C should receive antiviral drug treatment as early as possible to remove hepatitis C virus from the body, improve liver disease, and prevent and reduce the occurrence of cirrhosis and liver cancer.