SLE is a systemic autoimmune disease that can invade multiple systems and organs of the body, and therefore has a complex and diverse clinical presentation. Most of the cases of SLE start insidiously, and may initially show persistent low fever, fatigue, loss of appetite, wasting, etc., or mild arthritis, rash, occult nephritis, hypocytosis, mild anemia, thrombocytopenia, etc. As the disease progresses, multiple system and organ damage may gradually appear. As the disease progresses, multiple systems and organ damage may gradually appear, such as invasion of skin and mucous membranes, such as butterfly-shaped erythema, photosensitivity, nodular erythema, oral or nasal mucosal ulcers, etc.; invasion of the plasma membrane cavity, such as pleurisy, pleural effusion, peritoneal effusion, pericardial effusion, etc.; invasion of joints and muscles, such as joint swelling and muscle pain; invasion of the kidneys, such as proteinuria, hematuria, edema, hypertension, etc.; invasion of the Invasion of the nervous system, headache, epilepsy, mood disorders, etc.; invasion of the digestive system, abdominal pain, hepatosplenomegaly, abnormal liver function, etc.; invasion of the eye, vision loss, fundus bleeding, optic disc edema, etc. In some critically ill patients, hemolytic anemia, granulocyte deficiency, acute renal insufficiency, alveolar hemorrhage, severe pneumonia, acute abdomen, coma, etc. may also appear, which may be life-threatening if not treated in time. The symptoms of SLE are diverse and involve multiple systemic organs, and the severity of the disease varies from person to person. In general, women of childbearing age and those with a family history of lupus should consider the possibility of SLE if they develop symptoms and signs involving multiple systemic organs that are difficult to explain by conventional diseases and seek prompt medical attention.