Pyelonephritis is categorized into acute pyelonephritis and chronic pyelonephritis. Acute pyelonephritis can be recovered within 14 days for mild cases, while chronic pyelonephritis takes a longer time to treat. 1. Acute pyelonephritis: Acute pyelonephritis can be treated with oral medication, and mild cases can return to normal within 14 days. Commonly used drugs include quinolones (e.g., ofloxacin, ciprofloxacin, levofloxacin), semi-synthetic penicillins (e.g., amoxicillin), cephalosporins (e.g., cefuroxime), etc. The first occurrence of acute pyelonephritis can be treated by oral medication. The causative organism of acute pyelonephritis for the first time is mostly Escherichia coli, and the treatment should be started immediately after urine bacterial specimen is taken, and the drugs that are effective against gram-negative bacilli are preferred. if the effect is obvious in 72 hours, there is no need to change the drugs, or else the antibiotics should be changed according to the result of the drug sensitivity. 2. Chronic pyelonephritis: The key to the treatment of chronic pyelonephritis is to actively search for and remove susceptibility factors, and the treatment time is relatively long. The treatment is the same as that for acute pyelonephritis. Patients with pyelonephritis should go to the hospital in time and receive standardized treatment under the guidance of a professional physician. The medication should be used according to the doctor’s prescription, do not self-medicate.