If bilateral ankle swelling occurs, it cannot be ruled out that it is caused by some systemic diseases, such as rheumatoid arthritis or gout. However, if one side of the ankle is swollen, it is generally considered to be caused by trauma, overwork or thrombosis. First of all, trauma can lead to ankle swelling, which will lead to ankle mobility and pain, and the swelling will gradually increase within 24 hours after the injury, so it is not difficult to identify. Overexertion can also lead to unilateral ankle swelling. If the patient is used to standing on one foot, this ankle will generate excessive pressure, which can also lead to swelling. Finally, blood clots can also lead to swelling of one ankle, which is still relatively common in clinical practice. Patients with frequent episodes of symptoms may choose to go to the hospital for further consultation.