Patients with reflux esophagitis who suffer from insomnia, dreaminess and fatigue can take medications to treat esophagitis and medications to relieve insomnia. 1. Drugs to control reflux esophagitis: acid-suppressing drugs, such as omeprazole; potassium ion-competitive acid blockers, such as vornodine; mucosal-protecting drugs, such as teprenone and thioglycollate; and drugs to improve peristalsis of the digestive tract, such as domperidone and mosapride, can be taken. 2. Relief of insomnia drugs: you can take sedative-hypnotic drugs, such as oxazepam, eszopiclone, alprazolam, clonazepam and so on. If accompanied by depression and anxiety, you can also take sertraline, venlafaxine and so on. However, it is necessary to identify the cause of insomnia, sleeplessness and fatigue, so that the cause of the disease can be identified and the treatment can be carried out. In addition, all of the above drugs should be used under the guidance of a professional physician.