Generally speaking, anal suppositories to reduce fever will usually reduce the fever within an hour or so. But the specifics vary from person to person. In the current clinic, for the people with fever, the first choice of physical cooling, if there is no effect or the temperature continues to rise, then choose the drug cooling, the anus plug antipyretic pessary is commonly used medication antipyretic method, commonly used pessary indomethacin pessary and so on, in the use of about an hour after the fever can be reduced. But for people with more serious conditions, it takes longer. At this time, you can make the combination of medication and physical antipyretic application, antipyretic effect will be faster. When high fever persists, it is recommended to complete all the examinations to clarify the cause of the disease and timely treatment.