Eyes that keep jumping and blinking are actually a sign of blepharospasm. This is a common focal dystonia disorder, a movement disorder caused by neurological dysfunction of the inner nucleus accumbens. The specific pathogenesis is not yet clear. In the early stages of the disease, some patients may have sensory artifacts that can be relieved transiently by touching the forehead or cheeks with the hand or by wearing sunglasses, while in patients with a long course of the disease, these methods are less effective. However, it is certain that excessive fatigue, stress, and eyestrain can aggravate the symptoms of the disease, so patients should ensure sufficient sleep and adjust their mindset in daily life will help to reduce the symptoms of the disease. In terms of treatment, Botox can relax muscles by organizing the release of acetylcholine from motor nerve endings. In layman’s terms, this means that the normal function of the muscles around the eyes is restored by eliminating their excessive contraction. At the same time, botulinum toxin treatment for blepharospasm does not affect the muscles in the lower middle region, so it has relatively little effect on facial expression; however, some patients may still feel some stiffness around the eyes that is unnatural, and the frown lines between the eyebrows may decrease or disappear when frowning, but these effects are generally self-limiting and do not persist for a long time. According to foreign literature, the duration of efficacy of treatment of blepharospasm with botulinum toxin averages 2.5 months, but the treatment dose is lower than in China. The efficacy in domestic patients usually lasts for more than 3 months, with a few up to 6 months. When it comes to the timing of injections, the interval between injections should be at least 3 months, and re-injection is usually an option if symptoms recur and affect eye function and daily life. If a patient with blepharospasm is experiencing ineffective or unremarkable results from Botox treatment, the first step is to return to the doctor about 2 weeks after treatment so that an experienced physician can determine whether the ineffectiveness is due to insufficient dose or side effects, so that the dose can be adjusted for the next treatment. Patients who are unable to make a follow-up visit in time can also use the medical platform to make an online visit so that the physician can make a determination at the follow-up visit. The incidence of side effects from Botox for blepharospasm is relatively low and is generally reversible, with full recovery in 2-8 weeks. The most common side effects are muscle weakness associated with the target muscle and local bruising and edema. The former manifests itself as ptosis, blurred vision or even double vision. Rarely, side effects manifest as generalized flu-like symptoms or allergies. Does the effectiveness of Botox treatment diminish significantly as the number of injections increases? Most of the available clinical studies have confirmed the long-term effectiveness of botulinum toxin in the treatment of ocular spasm, and we have come into contact with a large number of patients who have been treated on a long-term, regular basis during our clinical observations, and have not observed a definite diminution of efficacy after long-term treatment.