Tuberculous persistent peritoneal effusion needs to be treated for the cause of the disease as well as for the relief of the patient’s clinical symptoms. Tuberculous peritoneal effusion is most common in young and middle-aged people with a history of tuberculosis and a slow onset of the disease. 1. Etiologic treatment: use of anti-tuberculosis drugs such as isoniazid, rifampicin, pyrazinamide, ethambutol, and streptomycin. 2. Symptomatic treatment is mainly used to relieve clinical symptoms. (1) General treatment. Attention to rest, low-sodium diet, reasonable control of fluid volume. (2) Application of diuretics. Starting from small doses, potassium-excreting diuretics and potassium-preserving diuretics are used alternately or in combination. (3) Increase plasma colloid osmotic pressure. (4) Peritoneal puncture to release fluid. It is used in patients with obvious clinical symptoms such as abdominal distension or in tuberculous peritoneal fluid with worsening general condition. If you suffer from persistent tuberculous peritoneal effusion, you should actively cooperate with the doctor’s treatment and do not stop the treatment, so as not to cause the continuous development of the disease, and finally even life-threatening.