Leukoplakia of the laryngeal mucosa

  Precancerous lesions are a group of diseases that are more likely to become cancerous than normal mucosa and are generally considered to be due to morphologic changes in the epithelium as a result of chronic irritation by local factors or as a local phenotype of systemic disease.11 Precancerous laryngeal lesions consist of a variety of diseases with different clinical manifestations but similar histopathologic patterns and biological features, including laryngeal mucosal leukoplakia, adult laryngeal papilloma, and chronic hypertrophic laryngitis. The clinical and histopathological terminology of laryngeal precancerous lesions, especially laryngeal leukoplakia, has been changing over the past century, and only in the last few years has a more unified opinion been reached regarding their diagnosis and treatment.