Stage 4 Nephroblastoma is essentially incurable. Nephroblastoma is an abdominal malignant tumor disease, and it is the most common type of renal malignant tumor for children. According to the COG staging system, stage 4 nephroblastoma refers to stage IV nephroblastoma, which means that the tumor cells in the patient’s body have undergone distant metastasis, such as brain metastasis, lung metastasis, bone metastasis, etc., which means that the patient’s condition has already progressed to an advanced stage, so the possibility of curing the disease is almost zero. Although stage IV nephroblastoma cannot be cured, patients can still control the disease effectively through surgery, radiotherapy and other ways, which can improve the prognosis of nephroblastoma and reduce the harm of the disease. If abnormal lesions are found in the kidneys through examination, early intervention should be carried out.