There is no such thing as “the best time to take Metformin Extended-Release Tablets twice”, it is generally recommended to take with meals. Metformin extended-release tablets can inhibit hepatic glucose synthesis and reduce intestinal absorption of glucose, increase the utilization and uptake of glucose by peripheral tissues, improve insulin sensitivity, and ultimately lower blood glucose. Twice daily Metformin Extended-Release Tablets are generally recommended to be taken with a meal, which can be divided into morning and evening; if taken once daily, it is recommended to be taken with dinner, and the drug should be swallowed intact and should not be broken, chewed or crushed. Patients who require treatment with Metformin Extended-Release Tablets should use the medication under the supervision of a doctor.