High uric acid is mainly due to purine metabolism disorders and (or) uric acid excretion caused by a reduction in the use of drugs to inhibit uric acid production (such as allopurinol, febuxostat), to promote uric acid excretion of drugs (such as phenylbromarone) to reduce uric acid. 1. Inhibition of uric acid production drugs: the main role is to inhibit the production of uric acid, so as to play a role in reducing uric acid, including allopurinol and febuxostat. Allopurinol medication process pay attention to exfoliative dermatitis type of rash, gastrointestinal reactions (such as diarrhea, nausea, vomiting, etc.), blood system damage (such as leukopenia, etc.) and other side effects occur. It is contraindicated in patients with allergies, severe hepatic and renal insufficiency. Febuxostat application may cause hepatic failure, allergy and other adverse reactions. Patients who are using mercaptopurine, allergic to the product and other conditions are prohibited. 2. Promote uric acid excretion drugs: such as benzbromarone, which has the effect of inhibiting the reabsorption of uric acid in renal tubules to increase uric acid excretion, and thus can reduce the concentration of uric acid in the blood, but may cause diarrhea, stomach upset, nausea and other symptoms. It is contraindicated in allergic persons, persons with moderate to severe renal impairment and pregnant women. It is recommended that patients with high uric acid go to the hospital in time, and the above drugs should be used under the guidance of a doctor, do not self-medicate.