Blisters i.e. blisters. Large transparent blisters on the face may be caused by herpes simplex, herpes zoster, milia, etc. Targeted treatment, such as medication, needs to be carried out under the guidance of a doctor. 1. Herpes simplex: a skin disease caused by herpes simplex virus infection, manifested by clustered blisters, skin erosion and crusting, local pain. Consider oral vasiclovir, acyclovir and other antiviral drugs; can be used externally with glycerite lotion, 3% acyclovir ointment and so on. 2. Herpes zoster: due to the infection of varicella zoster virus, can also cause large blisters on the face. At this time, we need to actively anti-viral treatment, such as oral acyclovir, vasiclovir, analgesic and nutritive nerves, such as oral pregabalin, methylcobalamin and so on. If secondary bacterial infection occurs, combined topical antibiotics such as mupirocin ointment are also needed. 3. Corns: also called prickly heat, the main symptom is the appearance of raised blisters or papules on the skin, some patients will have tingling or itching. Topical use of glycerite lotion, prickly heat powder, etc.; when the infection is serious, oral amoxicillin, ampicillin and other antibiotics. At the same time to keep the surrounding environment cool, clean and dry skin. But do not rule out other factors, it is recommended that patients seek medical attention in a timely manner, by the doctor to clarify the cause, give targeted treatment, the above drugs need to comply with the doctor’s instructions to use, do not blindly self-confidence in the use of drugs.