Systemic vasculitis is clinically known as systemic vasculitis, which needs to hang up the rheumatology and immunology department or peripheral vascular department (vascular surgery). Systemic vasculitis is an autoimmune disease in which inflammation and destruction of blood vessels are the main pathological changes, and the clinical manifestations are different because of the different sizes, types, and locations of the blood vessels involved, which may involve multiple organs throughout the body. Systemic vasculitis may develop alone or as a manifestation of other diseases, such as rheumatoid and systemic lupus erythematosus. The etiology and pathogenesis of systemic vasculitis are unclear, and may be related to infections, immune abnormalities mediated such as immune complex-mediated, antibody-directly mediated, and anti-neutrophil cytoplasmic antibody-mediated. Systemic vasculitis requires treatment in a rheumatology department or a peripheral vascular department (vascular surgery).