Melanosis at joints is a common clinical symptom, which can be seen in physiological factors such as local friction and pathological factors such as post-inflammatory hyperpigmentation, Riel melanosis, etc., which need to be removed reasonably according to the different causes of the disease through general treatment, medication, physiotherapy and other ways. 1. Physiological factors: daily friction on joints is more frequent, which leads to local skin pigmentation. Firstly, the friction on joints can be minimized, and secondly, decoloring agents such as hydroquinone cream can be applied externally as appropriate under the guidance of doctors to reduce the local skin pigmentation. 2. Pathologic factors: (1) Post-inflammatory hyperpigmentation: it is a common symptom left after the healing of various acute or chronic inflammatory diseases of the skin. Under the guidance of the doctor, decolorizers such as hydroquinone cream can be applied externally, and medicines such as retinol cream can be used jointly to promote the renewal of the epidermis and to reduce the melanin deposition. If necessary, you can also follow the doctor’s instructions oral tranexamic acid, glutathione and other drugs to inhibit the proliferation of melanocytes, to relieve the symptoms of hyperpigmentation. In addition, chemical exfoliation and photoelectricity treatment can be applied under the guidance of the doctor to lighten the local hyperpigmentation. (2) Ryle’s melanosis: the cause of this disease is not known, it may be related to light sensitivity or exposure to coal tar, which leads to the phenomenon of hyperpigmentation in the area around the lesion. Patients should look for and avoid triggers, and take occupational precautions to avoid re-exposure to asphalt, coal tar, etc., and take daily sun protection. Under the guidance of doctors, patients can use hydroquinone cream and other decolorizers externally to improve the symptoms, and systematically apply vitamin C, tranexamic acid, glutathione and other drugs to resist oxidation and inhibit the proliferation of melanocytes, etc., and if necessary, can also follow the doctor’s instructions to use laser treatment to improve the symptoms, etc.. In the inflammatory stage, oral glucocorticoid drugs such as prednisone can also be taken as prescribed by the doctor. It is recommended that patients with melanosis in the joints should go to regular hospitals in time to get a clear diagnosis and standardized treatment under the guidance of professional doctors.