Positive human leukocyte antigen B27 is an auxiliary diagnostic index of ankylosing spondylitis, so some patients with joint discomfort symptoms, the doctor will prescribe human leukocyte antigen B27. ankylosing spondylitis usually occurs in young adults, sometimes the disease may be more insidious, the majority of the patients’ first symptom is the involvement of the sacroiliac joints, the pain aggravated by activity, the later severe cases may involve the entire spine, resulting in a bamboo-like spinal changes. Later, in severe cases, the entire spine may be involved, resulting in bamboo-like spinal changes. In addition, ankylosing spondylitis can also involve organs outside the joints, such as the heart and nervous system, but the probability of occurrence is not very high. There is currently no cure for ankylosing spondylitis, but if detected early and treated with medication, most people have a very good prognosis and improved quality of life.