Low cortisol can lead to a variety of diseases, including gastrointestinal disorders, low blood pressure, hypoglycemia, electrolyte disorders, reproductive system dysfunction, weakening of resistance, etc. It is recommended to consult a doctor in time for further examination to clarify the diagnosis and target treatment. 1. Gastrointestinal disorders: patients with low cortisol may suffer from loss of appetite, indigestion and other discomforts. 2. Hypotension: Cortisol can cause water and sodium retention. When cortisol is low, blood volume decreases, leading to hypotension. 3. Hypoglycemia: low cortisol weakens gluconeogenesis and depletion of hepatic glycogen, which can lead to hypoglycemic symptoms. 4. Electrolyte disorders: when cortisol is low, blood volume decreases and antidiuretic hormone is released excessively, leading to hyponatremia and hyperkalemia. 5. Reproductive system dysfunction: low cortisol leads to loss of pubic hair and axillary hair, menstrual disorders or amenorrhea in women, but those with milder conditions can still have children; men often have hypogonadism. 6. Weakened resistance to infections and other stresses: cortisol has an anti-shock effect, etc. If cortisol is low, adrenal crisis can occur when stress occurs. If the above symptoms occur, please go to the hospital for consultation and examination in time, and clarify the cause of the disease with the help of doctors and carry out standardized treatment.