Fever can be transfused with platelets if the temperature does not exceed 38.0°C. If the fever is high, it needs to be treated with antipyretic treatment and platelets transfused after the temperature has dropped. The main reason why hyperthermia requires fever reduction before platelet transfusion is that hyperthermia can consume platelets and greatly reduce the effectiveness of platelet transfusion. Moreover, platelet transfusion in patients with high fever can mask the adverse reactions associated with platelet transfusion, such as the emergence of fever and other adverse reactions. Hyperthermia can not transfuse platelets is relative, if the patient’s platelets are severely reduced, there is active bleeding, such as gastrointestinal bleeding, cerebral hemorrhage, etc., even if hyperthermia, we must follow the doctor’s advice to transfuse platelets, because life safety is the first.