Acute pyelonephritis combined with fever, mostly due to the disease combined with bacterial infection, not recommended to use cold medicine for treatment, it is recommended to target the use of antibacterial drugs, etc. For the treatment of acute pyelonephritis, it is recommended to use antibacterial drugs. Clinically there is no cold medicine this kind of drug classification, usually said cold medicine, mainly for the cold caused by sore throat, cough, runny nose and other symptoms of the symptomatic drugs. Acetaminophen and other non-steroidal anti-inflammatory drugs in these medications have a certain effect on fever relief, but are not effective in treating the cause of pyelonephritis, so they are not recommended for use, and the treatment of pyelonephritis is based on antimicrobial therapy. According to the different pathogens of pyelonephritis infection combined with fever, quinolone antibiotics such as ofloxacin and ciprofloxacin, and cephalosporins such as cephalosporin can be chosen. However, it should be noted that quinolone antibiotics are contraindicated for children, pregnancy and lactation. In case of acute pyelonephritis combined with fever, it is recommended to go to the hospital in time, and the above drugs are recommended to be used under the guidance of clinicians.