Patients with asymptomatic hyperuricemia can take drugs that promote uric acid excretion or inhibit uric acid production for uric acid lowering treatment, supplemented by alkaline drugs such as sodium bicarbonate.
1. Promote uric acid excretion drugs: common uric acid excretion drugs such as benzbromarone, this kind of drugs can increase the excretion of uric acid, reduce the level of uric acid in the blood; during the period of taking the drug, you should drink a lot of water, alkalinization of the urine, in order to avoid uric acid in the urine to accumulate into the crystals.
2. Inhibit uric acid production drugs: common inhibitory effect of uric acid production of drugs, including allopurinol and febuxostat, etc., this kind of drugs can inhibit hypoxanthine or other purine metabolism into uric acid to achieve the effect of inhibiting uric acid production. HLA-B * 5801 gene-positive patients with a ban on allopurinol, the need to carry out the gene before taking the drug screening.
3. Alkaline drugs: sodium bicarbonate can alkalize the urine, so that uric acid is not easy to accumulate in the urine to form crystals; long-term use of large quantities of alkalosis can lead to metabolic alkalosis, the need for regular review.
Patients with asymptomatic hyperuricemia should use the above drugs under the guidance of a doctor, and should not use the drugs on their own to avoid adverse effects.