Melasma is a common, hyperpigmented skin mucosal disease. There are many good treatments that can be applied, such as oral vitamin C with vitamin E, which can help to remove the spots. However, patients should note that vitamin C needs a relatively large dose to be effective and needs to be applied continuously within a certain period of time. For example, patients take 100mg each time, 3 times a day, but patients need to take it continuously for 2 weeks and then stop using it for 2 weeks. Meanwhile, vitamin E is also needed to be applied continuously for about 3 months to see the effect of melasma fading. However, in the clinic, in order to improve the cure rate of patients, it is recommended that patients should also apply such as laser, fruit acid resurfacing, and other methods such as vitamin E ointment topical application.