The recurrence of proteinuria after hormone dosage reduction may be related to hormone dependence and the effect of drug withdrawal. 1. Hormone dependence: After the kidney function is damaged, the therapeutic efficacy of the drug for the lesion will be reduced, that is, the body’s ability to absorb the drug is reduced, coupled with the patient’s physical condition and the influence of age and other factors, which will lead to hormone dependence of the patient. 2. Discontinuation effect: hormone has the role of regulating sugar and protein, also has a certain anti-inflammatory effect, but can not fundamentally clear the kidney inflammation, can repair some of the damage is relatively mild renal function, need to be taken for a long period of time, a short period of time to take medication is likely to cause a decline in the therapeutic effect or proteinuria rebound. It is recommended that patients go to the hospital for further examination to clarify the cause of the disease and then treat the symptoms, do not use medication privately, so as not to cause adverse consequences.