Factors that lead to puffy eyelids in the morning include physiologic and pathologic, and pathologic factors commonly include eye diseases, kidney diseases, and so on. Due to the thin skin of the eyelids and the laxity of the tissues under the eyelids, under the influence of physiological factors such as drinking a lot of water before going to bed, crying, and staying up all night, it can lead to poor blood reflux and eyelid swelling. Usually, it can subside naturally and will not affect the health of the body. When eyelid swelling recurs or is accompanied by other uncomfortable symptoms, we need to be alert to pathological factors. If there are symptoms of redness, pain and swelling in the eyes, it is necessary to consider blepharitis, conjunctivitis and other eye diseases. If, in addition to swelling of the eyelids, edema also occurs in the ankles, feet and other parts of the body, accompanied by an increase in froth in the urine and a decrease in the amount of urine, it is necessary to consider nephrotic syndrome, acute nephritis and other renal pathologies. These are some of the possible causes of eyelid edema, and it is recommended to consult a doctor in time for professional diagnosis.