Leukoplakia, also known as leukoplakia and pemphigus, is usually caused by endocrine disorders, heredity and melanin loss. 1. Endocrine disorders: the abnormal mechanism of melanin formation in the body leads to melanin not being able to be secreted normally, resulting in melanin loss, thus forming leukoplakia. 2. Heredity: Leukoplakia is hereditary. Generally speaking, if the parents suffer from this disease, it is very likely that the disease-causing gene will be passed on to the next generation through heredity. 3. Melanin loss: It is mainly caused by the loss of melanin in the skin. When the loss of melanin reaches a certain level, white spot disease will appear on the skin. If a patient suffers from white spot disease, it is recommended to consult a doctor for examination in time and choose the appropriate treatment according to the doctor’s opinion.