Creatinine does not come down after dialysis, it may be because dialysis is not sufficient or complications are not well controlled. Dialysis is an effective method of kidney insufficiency treatment using dialysis machine. In case of renal insufficiency, metabolites and wastes in the body like creatinine and urea nitrogen cannot be eliminated from the body through the kidneys. And through the hemodialysis machine, the machine can be utilized to remove the excess of these wastes out of the body, so as to maintain the relative normal function of the kidneys. In patients with renal insufficiency, if the urea nitrogen and creatinine components have been accumulated for a very long time, the concentration is very high. Then there needs to be a process of treatment through dialysis, and their values will gradually decrease, not the first dialysis these components will be significantly reduced. Some patients need to be dialyzed several times in a row before their creatinine slowly decreases. Secondly, after starting regular dialysis, it is not only necessary to assess the level of blood creatinine, but also the overall indicators of the patient, such as the general nutritional status, including the degree of anemia, the level of albumin in liver function; and the patient’s cardiac function, blood pressure and other complications. These indicators are more important to the patient’s prognosis. If the patient’s above complications are not well controlled, more creatinine and other toxins will be produced, and there may also be a situation where creatinine cannot be reduced after dialysis. The complications need to be treated aggressively and in accordance with the doctor’s instructions. Creatinine failure after dialysis should be evaluated by the doctor according to the patient’s specific situation, and the cause should be clarified and targeted treatment should be carried out.