The latest mutated strains of the new coronavirus may have symptoms such as runny nose, headache, sore throat, sneezing, persistent cough, and hoarseness. Viruses generally mutate in the direction of adapting to their environment as they evolve. Neocoronaviruses are RNA viruses and mutate more rapidly. There are currently more than 1,000 types of neocoronavirus mutations, and the main ones to focus on are: alpha, beta, gamma, delta, and omicron viral strains. The Omicronjon novel coronavirus variant strain was first discovered in September 2020. It is now endemic in more than 100 countries around the world, replacing the delta strain as the predominant strain of influenza today. It is more infectious and spreads more rapidly, but infected patients have fewer severe and critical illnesses and lower mortality rates. Common symptoms in patients with omicron include runny nose, headache, sore throat, sneezing, persistent cough, hoarseness, loss of smell, and severe acute respiratory distress syndrome, hypoxemia and ultimately death. Omicron may accelerate the spread of the new coronavirus, and everyone should receive vaccination and booster shots as soon as possible to enhance the antibody level. Secondly, we still need to do a good job of daily protection, wear masks when going out, and follow the rules of epidemic prevention. Tips] The “new coronavirus pneumonia” and “new coronavirus pneumonia” mentioned in this article have been renamed to “new coronavirus infection” on December 26, 2022, as announced by the National Health Commission.